How long does Tramadol stay in your system?

Typically after undergoing surgery and in deep pain, you’ll be given pain relievers such as Tramadol. You can also take it when in moderate pain to feel better. It has various brand names like ConZip, Rybix, FusePaq Synapyrin, and Ryzolt. But then, how long will this medication last in your body? Understanding the duration it can stay in your body will help you in taking the right precautions and reduce its usage. This is because you can become an addict and entirely depend on it. Read this informative article and understand all you need to know about this pain reliever.


How it Works

Like any other pain relievers, Tramadol works by attaching to opioid receptors in your brain then blocks the pain signals. However, it has its effects on your body, like increasing the functioning of serotonin and norepinephrine. The two are crucial chemical messengers in your brain which help your body to interpret different signals.

You do take pain relievers to help prevent being in agony and to do other things smoothly. However, when you take Tramadol, it will not eliminate the pain you’re feeling. It will only reduce it for some time before coming back.

Side Effects

As Tramadol reacts with your system, it will make you have breathing problems, and your eye’s pupils will become narrower. Another effect that you may fail to see is the long digestion hours which can lead to constipation. The effects come about since it makes your blood vessels enlarge.

Other effects you’ll experience when you’re using this medication include;

How Long Will You Feel Its Effects on Your Body?

To feel the effects of Tramadol in your body, it can take around one to two hours, depending on the type you took. If you took the extended relief pill, it would take time to show in your body. It can take them around 12 or 24 hours to start reacting with your body. Tramadol injections or drops react faster in your body. They can take between 30 minutes and one hour, but your effects you’ll hear for about four or six hours.

How Long Will It Last in Your System?

Tramadol can take up to nine hours in your body or more, depending on how many doses you did take. For your body to get rid of half an amount, it requires a half-life. But to eliminate it, your body needs six times longer than that of half-life. When you take this drug, it goes to the liver, where it’s broken down before the kidney excretes it in the urine. In that process, 30% of the Tramadol in the urine comes out unaltered. But the other percentage becomes metabolites which are also excreted.

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Tramadol Detection Times

Can There Be False Results?

It’s hard getting false-positive results of this drug since few substances can cause that. However, Tramadol or its metabolites can cause false-positive results for PCP or buprenorphine. So, let the doctors know you’ve been using this pain reliever if you go for tests.

What Can Affect its Detection Time in Your Body

Several factors can affect the detection of this drug in your body. For example, if you are a poor metabolizer of Tramadol. This condition results from having a low activity of the CYP2D6 of cytochrome P-450, which takes longer to break it down. For this reason, it will be active in your blood for more time than it should.

Suppose you take some other medicines that also reduce the effectiveness of this pain reliever you’ll be risking since it’ll slow the process.

If you take the pill, its absorption and excretion will take longer than if you got an injection.

Other factors include:


If you overdose, it will take more time to metabolize.

How often you use it

If you take this pain reliever regularly, it will accumulate in your body. And suppose the last pills have not been fully broken down, it will take more time to metabolize the additional doses.

Kidney and liver complications

Having kidney or liver problems can affect the rate at which your body eliminates waste which will interfere with the detection time.


Your age will also affect the detection of this drug in your system. If you’re old, your metabolic rate becomes slow, and you may also need other medications, which can affect the results. Old age may also make you have kidney and liver problems which will also cause low metabolism.


Metabolism can also affect the detection time. This is because having a lower metabolic rate increases the breakdown duration. Your diet, body composition, and fitness will also affect metabolism.

How to Eliminate Tramadol from Your Body?

If you want to be free from this drug, the only way out is to stop using it so that your system gets time to clear itself. Suppose you’ve been overdosing; look for Narcan, which is a nasal spray that’s able to reduce its effects. But it won’t hasten the elimination process. But you might need extra Narcan to wash out its remains from your body.

Sign of Overdosing

It’s always advisable to take the right amount of this drug as your doctor did prescribe for you. You should also not crush the extended relief pills since they will contribute to overdose. To know when you’ve taken an overdose, you’ll see the following symptoms;

While using this medication avoid alcohol, or medications containing alcohol. Also, it would help if you did not mix it with certain drugs, which can lead to life-threatening situations.

Seeking for Assistance

Since using this drug can be addictive, you can experience withdrawal symptoms when discontinuing its use. You might become anxious, have painful muscles, lack sleep or sweat. You’ll get these symptoms two or three days after stopping its use, although they’ll disappear within two weeks. But usually, your doctor provides you with a discontinuation program to prevent having these symptoms.

The treatment choices for opiate use disorder are:


Although Tramadol is a good pain reliever, it’s not good to overdose or uses it longer. It’s highly addictive and with serious side effects on your body, but stopping its usage is never easy. Since it can take up to 72 hours in your body, it’s wise to look for ways to get rid of it. Doing this is challenging but seek your doctor’s help to help you get out of this risky drug.